Iftikhar Ahmed dismissed three Hyderabad Kingsmen batters in a single over, removing Saim Ayub, Usman Khan, and Sharjeel Khan to leave the innings in trouble.
Hyderabad Kingsmen were reduced to 34 for 4 in 4.6 overs, with Sharjeel Khan bowled by Iftikhar Ahmed after scoring only two runs.
Earlier, Maaz Sadaqat contributed 17 runs from eight balls before falling to Iftikhar Ahmed, while Saim Ayub managed 14 runs before being caught by Mohammad Haris.
At the crease, Kusal Perera remained unbeaten on 24 from 13 balls, supported by Marnus Labuschagne with 18 runs from 15 deliveries during their partnership.
Iftikhar Ahmed completed four overs, conceding 21 runs and claiming four wickets, producing the most decisive bowling spell of the innings for Peshawar Zalmi.
Peshawar Zalmi had opted to bowl first after winning the toss, with Hyderabad Kingsmen struggling against disciplined bowling on a slow and low Karachi pitch.
