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A revolutionary milestone was achieved at Shanghai Jiao Tong University, where a team led by Dr. Fei Wang has developed a DNA-based supercomputer capable of running over 100 billion tasks simultaneously.
This innovative system uses the inherent properties of DNA molecules to create “liquid computers.” Traditionally, DNA is known for its role in carrying genetic information. However, researchers are now exploring its potential as a computational tool.
The new system utilizes DNA-based programmable gate arrays (DPGAs), which are built from short, single strands of DNA. These DPGAs are highly flexible and scalable, with each variety capable of being programmed into more than 100 billion possible circuit designs by adding specific molecular “keys.”
In practical demonstrations, the team linked DPGAs with approximately 500 DNA strands to solve quadratic equations and calculate square roots. Input molecules trigger chemical reactions within the circuit, analogous to electrical currents in conventional computers, and the results are observed through fluorescent signals from tagged molecules.
Dr. Wang’s team successfully developed a DPGA capable of distinguishing between small RNA molecules, including those associated with renal cancer. This demonstrates the potential for DNA computing to detect diseases at the molecular level, potentially leading to highly parallel and energy-efficient diagnostic devices.
